This desktop gap analysis identified potential strengths and weaknesses in national policy frameworks in 52 key documents relevant to plastic pollution in ten Pacific Large Ocean Small Island Developing States (LOSIDS). The study found considerable gaps in the vertical and horizontal integration of plastic pollution-related policy, and a lack of access to current science-based evidence on plastic pollution including evidence related to human health impacts and microplastics. The study concludes that, even if Pacific LOSIDS were to include best practice management of plastic pollution across all policy frameworks, they could not prevent plastic pollution, and that a plastic pollution convention is needed.